Integrated Electro?Biocatalysis for Amine Alkylation with Alcohols

The integration of electro and bio-catalysis offers new ways making molecules under very mild, environmentally benign conditions. We show that TEMPO mediated electro-catalytic oxidation alcohols can be adapted to work in aqueous buffers, with minimal organic co-solvent, enabling biocatalytic reductive amination using the AdRedAm enzyme. combined process a approach amine alkylation native alcohols, key bond formation chemical economy is currently achieved via precious metal-catalyzed hydrogen-borrowing technologies. electrobio transformation effective for primary secondary undergoing coupling allyl, propargyl, benzyl, cyclopropyl amines, has been use solid-supported ease operation.